Determination of Insulin Resistance and Dyslipidemia after treatment with selective Anti-Depressants in case of Major Depression

Introduction: Depression can present a plethora of symptoms, such as loss pleasure, feelings guilt, low selfesteem, and disturbed sleep or appetite. Selective Serotonin Re-uptake Inhibitors (SSRIs) are considered themainstay treatment for depression. Several studies suggest that antidepressants increase the risk developingmetabolic complications including Insulin Resistance (IR) dyslipidemia, thus leading to poor health outcomes.This study would provide review depression IR examine side effects anti-depressants oftenused treat depression.Material & Methods: It was cross-sectional analytical conducted at Department Biochemistry,College Medicine Sagore Dutta Hospital, in collaboration with Psychiatry. Patients attendingthe psychiatric OPD, who newly diagnosed Major Depressive Disorder (MDD) orrecurrent depressivedisorder were selected. Age gender matched healthy family members patients chosen controls.Results: Significant alteration Body Mass Index (BMI), Hamilton Scaling (HAM-D), High DensityLipoprotein (HDL) Low Density Lipoprotein (LDL )with non-significant variation HOMA-IR, TotalCholesterol Triglyceride levels found